MEDICINE'S GREAT ALEXANDER



Scotland born Sir Alexander Fleming, FRS FRSE FRCS, was a physician and microbiologist who discovered the world's first antibiotic, Penicillin...

Son of a farmer couple Hugh and Grace, Fleming a gold medalist from St. Mary's Hospital Medical School, London, in 1908, served as a physician during World War I...

Though aspiring to be a surgeon, Fleming took up a temporary post in the Inoculation Department at St. Mary's Hospital, where his mentor, bacteriologist and immunologist, Sir Almroth Edward Wright's ideas inspired Fleming to pursue research and experimentation...

As a bacteriologist with Royal Army Medical Corps during World War I, Fleming studying wound infections in a lab in Boulogne, France, noted that antiseptics commonly used then were ineffective. His recommendation that wounds be kept just dry and clean got no takers...

As assistant director of St. Mary's Inoculation Department after the war, Fleming's first significant contribution to medical research was his discovery of Lysozyme, an antiseptic enzyme present in body fluids. He soon realised that lysozyme had no effect on destructive bacteria...

Resuming work after a month's vacation, in September 1928, Fleming noted that a culture of Staphylococcus aureus bacteria he had left out had been destroyed by a mold (later identified as Penicillium notatum)...

In Fleming's own words, "When I woke up just after dawn on September 28, 1928, I certainly didn't plan to revolutionize all medicine by discovering the world's first antibiotic, or bacteria killer. But I suppose that was exactly what I did." And thus Penicillin was born...

With that discovery of the bacteria-destroying mold called Penicillin through rigorous research and experimentation, the era of antibiotics in modern healthcare came into being...

Scientists at University of Oxford scientists Howard Florey and Ernst Chain isolated and purified the antibiotic Penicillin which found extensive use in wound infection control during World War II. Florey, Chain and Fleming shared the 1945 Nobel Prize in Physiology and Medicine. The Inoculation Department of St. Mary's Inoculation Department was renamed the Wright-Fleming Institute...

Knighted in 1944, Sir Fleming passed away after a cardiac arrest on March 11, 1955, at his home in London, England...

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